A renaissance palace designed by Jacopo Barozzi da Vignola and built in 1524 by Baldassarre Peruzzi on behalf of Francesco Fusconi from Norcia.
Inherited around 1554 by his nephew Mons. Adriano Fusconi bishop of Aquino, then passed to Pighini, his grandchildren. The building was smaller than the present and was expanded by Alessandro Pighini in the early 17th century.
The Pighini had collected in the palace a collection of ancient works, including a statue of Meleagro with the wild boar, a Roman copy of the original attributed to Skopas (IV century BC).
John Evelyn mentions the palace in the entry from Sunday 6 November 1644:
“Here, in summer, the gentlemen of Rome take the fresco in their coaches and on foot. At the sides of this court we visited the palace of Signor Pichini, who has a good collection of antiquities, especially the Adonis of Parian marble, which my Lord Arundel would once have purchased, if a great price would have been taken for it.”